Tracy Luks, PhD | Li LAB IMAGING

Specialist

Phone

+1 415 514-6318

The primary focus of Dr. Luks's current research program is to use advanced neuroimaging to advance our ability to optimize treatment for patients with neurological and psychiatric disorders by predicting and monitoring disease progression, treatment response, cognitive function, and quality of life (QoL) in these patients. In subjects with psychiatric disorders, the goal of the research is to understand the biological mechanisms of impairment and guide and evaluate behavioral and pharmacological interventions with functional neuroimaging. This translational research program employs structural imaging and connectivity (anatomical MRI and DTI), functional neuroimaging and connectivity (fMRI), positron emission tomography (PET), and measures of neurocognitive and neurological status. Dr. Luks has conducted MRI, fMRI, and magnetoencephalography (MEG) studies of the neurobiological bases of cognitive functions in health control subjects, in patients with Depression, Autism, Glioma, Schizophrenia, Dementia, TBI, and in normal adolescents and aging.

Publications

Interoceptive brain network mechanisms of mindfulness-based training in healthy adolescents.

Frontiers in psychology

Tymofiyeva O, Sipes BS, Luks T, Hamlat EJ, Samson TE, Hoffmann TJ, Glidden DV, Jakary A, Li Y, Ngan T, Henje E, Yang TT

The University of California San Francisco Adult Longitudinal Post-Treatment Diffuse Glioma MRI Dataset.

Radiology. Artificial intelligence

Fields BKK, Calabrese E, Mongan J, Cha S, Hess CP, Sugrue LP, Chang SM, Luks TL, Villanueva-Meyer JE, Rauschecker AM, Rudie JD

Improving the Generalizability of Deep Learning for T2-Lesion Segmentation of Gliomas in the Post-Treatment Setting.

Bioengineering (Basel, Switzerland)

Ellison J, Caliva F, Damasceno P, Luks TL, LaFontaine M, Cluceru J, Kemisetti A, Li Y, Molinaro AM, Pedoia V, Villanueva-Meyer JE, Lupo JM

Understanding the association between fatigue and neurocognitive functioning in patients with glioma: A cross-sectional multinational study.

Neuro-oncology practice

Röttgering JG, Taylor JW, Brie M, Luks T, Hervey-Jumper SL, Phan S, Bracci PM, Smith E, De Witt Hamer PC, Douw L, Weyer-Jamora C, Klein M

PNOC015: Repeated convection-enhanced delivery of MTX110 (aqueous panobinostat) in children with newly diagnosed diffuse intrinsic pontine glioma.

Neuro-oncology

Mueller S, Kline C, Stoller S, Lundy S, Christopher L, Reddy AT, Banerjee A, Cooney TM, Raber S, Hoffman C, Luks T, Wembacher-Schroeder E, Lummel N, Zhang Y, Bonner ER, Nazarian J, Molinaro AM, Prados M, Villanueva-Meyer JE, Gupta N

Evaluation of major depressive disorder using 7 Tesla phase sensitive neuroimaging before and after mindfulness-based cognitive therapy.

Journal of affective disorders

Jakary A, Lupo JM, Mackin S, Yin A, Murray D, Yang T, Mukherjee P, Larson P, Xu D, Eisendrath S, Luks T, Li Y

Interactive Effects of Molecular, Therapeutic, and Patient Factors on Outcome of Diffuse Low-Grade Glioma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Hervey-Jumper SL, Zhang Y, Phillips JJ, Morshed RA, Young JS, McCoy L, Lafontaine M, Luks T, Ammanuel S, Kakaizada S, Egladyous A, Gogos A, Villanueva-Meyer J, Shai A, Warrier G, Rice T, Crane J, Wrensch M, Wiencke JK, Daras M, Oberheim Bush NA, Taylor JW, Butowski N, Clarke J, Chang S, Chang E, Aghi M, Theodosopoulos P, McDermott M, Jakola AS, Kavouridis VK, Nawabi N, Solheim O, Smith T, Berger MS, Molinaro AM

Longitudinal MR spectroscopy to detect progression in patients with lower-grade glioma in the surveillance phase.

Neuro-oncology advances

Avalos LN, Luks TL, Gleason T, Damasceno P, Li Y, Lupo JM, Phillips J, Oberheim Bush NA, Taylor JW, Chang SM, Villanueva-Meyer JE

Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kline C, Jain P, Kilburn L, Bonner ER, Gupta N, Crawford JR, Banerjee A, Packer RJ, Villanueva-Meyer J, Luks T, Zhang Y, Kambhampati M, Zhang J, Yadavilli S, Zhang B, Gaonkar KS, Rokita JL, Kraya A, Kuhn J, Liang W, Byron S, Berens M, Molinaro A, Prados M, Resnick A, Waszak SM, Nazarian J, Mueller S

In Reply: Postacute Cognitive Rehabilitation for Adult Brain Tumor Patients.

Neurosurgery

Weyer-Jamora C, Brie MS, Luks TL, Smith EM, Hervey-Jumper SL, Taylor JW

Improving the noninvasive classification of glioma genetic subtype with deep learning and diffusion-weighted imaging.

Neuro-oncology

Cluceru J, Interian Y, Phillips JJ, Molinaro AM, Luks TL, Alcaide-Leon P, Olson MP, Nair D, LaFontaine M, Shai A, Chunduru P, Pedoia V, Villanueva-Meyer JE, Chang SM, Lupo JM

T2 FLAIR Hyperintensity Volume Is Associated With Cognitive Function and Quality of Life in Clinically Stable Patients With Lower Grade Gliomas.

Frontiers in neurology

Luks TL, Villanueva-Meyer JE, Weyer-Jamora C, Gehring K, Jakary A, Hervey-Jumper SL, Braunstein SE, Bracci PM, Brie MS, Smith EM, Chang SM, Taylor JW

Postacute Cognitive Rehabilitation for Adult Brain Tumor Patients.

Neurosurgery

Weyer-Jamora C, Brie MS, Luks TL, Smith EM, Hervey-Jumper SL, Taylor JW

Resection of supplementary motor area gliomas: revisiting supplementary motor syndrome and the role of the frontal aslant tract.

Journal of neurosurgery

Young JS, Gogos AJ, Aabedi AA, Morshed RA, Pereira MP, Lashof-Regas S, Mansoori Z, Luks T, Hervey-Jumper SL, Villanueva-Meyer JE, Berger MS

Tumor metabolism and neurocognition in CNS lymphoma.

Neuro-oncology

Geng H, Tsang M, Subbaraj L, Cleveland J, Chen L, Lu M, Sharma J, Vigneron DB, Kurhanewicz J, LaFontaine M, Luks T, Barshop BA, Gangoiti J, Villanueva-Meyer JE, Rubenstein JL

Volumetric analysis of IDH-mutant lower-grade glioma: a natural history study of tumor growth rates before and after treatment.

Neuro-oncology

Huang RY, Young RJ, Ellingson BM, Veeraraghavan H, Wang W, Tixier F, Um H, Nawaz R, Luks T, Kim J, Gerstner ER, Schiff D, Peters KB, Mellinghoff IK, Chang SM, Cloughesy TF, Wen PY

Cognitive impact of lower-grade gliomas and strategies for rehabilitation.

Neuro-oncology practice

Weyer-Jamora C, Brie MS, Luks TL, Smith EM, Braunstein SE, Villanueva-Meyer JE, Bracci PM, Chang S, Hervey-Jumper SL, Taylor JW

Centrally Reduced Diffusion Sign for Differentiation between Treatment-Related Lesions and Glioma Progression: A Validation Study.

AJNR. American journal of neuroradiology

Alcaide-Leon P, Cluceru J, Lupo JM, Yu TJ, Luks TL, Tihan T, Bush NA, Villanueva-Meyer JE

Treatment-induced lesions in newly diagnosed glioblastoma patients undergoing chemoradiotherapy and heat-shock protein vaccine therapy.

Journal of neuro-oncology

Alcaide-Leon P, Luks TL, Lafontaine M, Lupo JM, Okada H, Clarke JL, Villanueva-Meyer JE

Sensorimotor Cortical Oscillations during Movement Preparation in 16p11.2 Deletion Carriers.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Hinkley LBN, Dale CL, Luks TL, Findlay AM, Bukshpun P, Pojman N, Thieu T, Chung WK, Berman J, Roberts TPL, Mukherjee P, Sherr EH, Nagarajan SS

Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps.

Biological psychiatry

Norman LJ, Taylor SF, Liu Y, Radua J, Chye Y, De Wit SJ, Huyser C, Karahanoglu FI, Luks T, Manoach D, Mathews C, Rubia K, Suo C, van den Heuvel OA, Yücel M, Fitzgerald K

Relationship of In Vivo MR Parameters to Histopathological and Molecular Characteristics of Newly Diagnosed, Nonenhancing Lower-Grade Gliomas.

Translational oncology

Luks TL, McKnight TR, Jalbert LE, Williams A, Neill E, Lobo KA, Persson AI, Perry A, Phillips JJ, Molinaro AM, Chang SM, Nelson SJ

Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT.

Acta neuropathologica

Pekmezci M, Rice T, Molinaro AM, Walsh KM, Decker PA, Hansen H, Sicotte H, Kollmeyer TM, McCoy LS, Sarkar G, Perry A, Giannini C, Tihan T, Berger MS, Wiemels JL, Bracci PM, Eckel-Passow JE, Lachance DH, Clarke J, Taylor JW, Luks T, Wiencke JK, Jenkins RB, Wrensch MR

Quantitative multi-modal MR imaging as a non-invasive prognostic tool for patients with recurrent low-grade glioma.

Journal of neuro-oncology

Neill E, Luks T, Dayal M, Phillips JJ, Perry A, Jalbert LE, Cha S, Molinaro A, Chang SM, Nelson SJ

Comparison of brain activation patterns during executive function tasks in hoarding disorder and non-hoarding OCD.

Psychiatry research. Neuroimaging

Hough CM, Luks TL, Lai K, Vigil O, Guillory S, Nongpiur A, Fekri SM, Kupferman E, Mathalon DH, Mathews CA

Evaluating metabolites in patients with major depressive disorder who received mindfulness-based cognitive therapy and healthy controls using short echo MRSI at 7 Tesla.

Magma (New York, N.Y.)

Li Y, Jakary A, Gillung E, Eisendrath S, Nelson SJ, Mukherjee P, Luks T

Intensive cognitive training in schizophrenia enhances working memory and associated prefrontal cortical efficiency in a manner that drives long-term functional gains.

NeuroImage

Subramaniam K, Luks TL, Garrett C, Chung C, Fisher M, Nagarajan S, Vinogradov S

Resting state magnetoencephalography functional connectivity in traumatic brain injury.

Journal of neurosurgery

Tarapore PE, Findlay AM, Lahue SC, Lee H, Honma SM, Mizuiri D, Luks TL, Manley GT, Nagarajan SS, Mukherjee P

Computerized cognitive training restores neural activity within the reality monitoring network in schizophrenia.

Neuron

Subramaniam K, Luks TL, Fisher M, Simpson GV, Nagarajan S, Vinogradov S

Dynamic activation of frontal, parietal, and sensory regions underlying anticipatory visual spatial attention.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Simpson GV, Weber DL, Dale CL, Pantazis D, Bressler SL, Leahy RM, Luks TL

Adolescent smokers show decreased brain responses to pleasurable food images compared with nonsmokers.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Rubinstein ML, Luks TL, Dryden WY, Rait MA, Simpson GV

Smoking-related cue-induced brain activation in adolescent light smokers.

The Journal of adolescent health : official publication of the Society for Adolescent Medicine

Rubinstein ML, Luks TL, Moscicki AB, Dryden W, Rait MA, Simpson GV

Atrophy in two attention networks is associated with performance on a Flanker task in neurodegenerative disease.

Neuropsychologia

Luks TL, Oliveira M, Possin KL, Bird A, Miller BL, Weiner MW, Kramer JH

Timing is everything: neural response dynamics during syllable processing and its relation to higher-order cognition in schizophrenia and healthy comparison subjects.

International journal of psychophysiology : official journal of the International Organization of Psychophysiology

Dale CL, Findlay AM, Adcock RA, Vertinski M, Fisher M, Genevsky A, Aldebot S, Subramaniam K, Luks TL, Simpson GV, Nagarajan SS, Vinogradov S

ERP correlates of anticipatory attention: spatial and non-spatial specificity and relation to subsequent selective attention.

Experimental brain research

Dale CL, Simpson GV, Foxe JJ, Luks TL, Worden MS

Parallel networks operating across attentional deployment and motion processing: a multi-seed partial least squares fMRI study.

NeuroImage

Caplan JB, Luks TL, Simpson GV, Glaholt M, McIntosh AR